There’s not much going on in Fresno — the “best little city in the USA,” where the best job you can get is the worst job you’ve ever had. Upbeat “Employee of the Month” at the shabby Fresno Suites Martha (Orange Is the New Black’s Natasha Lyonne) has no complaints with the gig or with life: she has a prime parking spot, a steady paycheck, and a straightish girlfriend who sometimes answers her calls. Martha’s co-dependent, sex addict sister Shannon (Arrested Development’s Judy Greer) should be grateful for any gainful employment following her recent firing from a teaching position and subsequent failed stint in rehab, but instead she can only muster (hilarious) sardonic one-liners while working as little as humanly possible.

As Martha gets pursued by her dreamy trainer (Parks and Recreation alum Aubrey Plaza, playing a lesbian after all of our prayers), Shannon’s hump-anyone’s-leg addiction gets them both into trouble when a mullet-sporting scumbag of a hotel guest is accidentally killed. With the help of a poetic and smitten coworker, the sisters hatch a plethora of schemes to get rid of the body, resulting in blackmail, a hip-hopping bar mitzvah, and oodles of fat purple dildos.

With a powerhouse production team helmed by two previous Frameline Award recipients — director Jamie Babbit (But I’m a Cheerleader, Frameline24) and producer Andrea Sperling (Transparent) — and penned by Karey Dornetto (Portlandia), the ensemble cast is a who’s who of quirk, with cameos by Fred Armisen, Clea Duvall, and Molly Shannon. Lyonne and Greer shine in that rarest of films — a dark comedy that allows women to be as inappropriate and flawed as men.